Spravato
(esketamine)Spravato (esketamine), a nasal spray that rapidly relieves symptoms of depression
Rapid results, highly effective
FDA-approved
Covered by most insurances
Highly Effective.
Life Changing Results.
Lasting Results
Patients sawgreater symptom improvementsfrom depression with 4 weeks of Spravato treatment compared to a placebo
Rapid Relief
A study showed a40% decline in depressionsymptoms on day one compared to a placebo
Covered by Insurance
Spravato is covered bymost insurance plans
Safe & Effective
Spravato isFDA-approved to treat depression, ensuring its quality
and safety
Minimal Side Effects
Some patients reportmild side effectslike dizziness, which typically go away in a few hours
How does Spravato (esketamine) work?
Euphoric and Energizing.
SpravatoworksbytargetingNMDAreceptorsinthebraintoinfluenceglutamatelevels,whichareassociatedwithmoodregulation.Byactivatingthesereceptors,Spravatocanhelpimprovedepressivesymptomsandproviderelief,forpeoplewhohaven’tfoundsuccesswithothertherapies.
Financial support is available
As low as $10/session
Patientscanpayaslittleas$10foreachSpravatoappointmentthroughthecost-savingsprogramslikeSpravatoWithMe&more.TheserebateprogramscandrasticallyreduceyourSpravatotreatmentcosts,dependingonyourout-of-networkbenefitsandcurrentdeductible.
What should I expect from Spravato Treatment?
1
Initial Consultation
A clinician will review your medical history, & assess prior treatments to ensure Spravato is right for you.
2
Insurance or Payment Plan
Spravato is covered by most major insurance plans, particularly when other treatments have not been effective.
3
Spravato Treatment Course
~2x/week, gradually reduced according to your care plan
Rapid relief in 1-2 hours
Spravato is self-administered nasal spray under the supervision of a healthcare professional. You will relax at the clinic for ~2 hours.
4
Continued Support
Many patients report significant improvements in mood and well-being. Your care team will work with you to develop a long-term treatment plan and offer resources for ongoing support.
Find a clinic offering Spravato near me
Find a Spravato provider that meets your insurance & personal preferences in the Big Leap directory
What patients say
about Spravato Therapy
"Spravato changed everything. Within weeks, I felt the weight lifting from my shoulders. It feels amazing to smile again." Sophie L.
"Spravato finally gave me relief from depression's grip. The fog cleared, and now I’m genuinely excited for tomorrow." Jasmine W.
"It was my last hope, and Spravato worked wonders. Each day now feels worth living." Neha B.
"Spravato lifted years of emotional heaviness. I now wake up with hope and energy for my family." Aaliyah J.
Spravato (Esketamine) vs. TMS
Understanding the Differences
How it works
Spravato
(Esketamine)Targets NMDA receptors to regulate mood and relieve symptoms
TMS
(Transcranial Magnetic Stimulation)Magnetic pulses stimulate specific brain areas to relieve symptoms over several weeks
Treatment
Spravato
(Esketamine)Self-administered nasal spray, administered under supervision
TMS
(Transcranial Magnetic Stimulation)20-40 minutes, magnetic pulses to the brain, awake during treatment
Side Effects
Spravato
(Esketamine)Mild: dizziness, nausea, dissociation
TMS
(Transcranial Magnetic Stimulation)Very mild: scalp discomfort or headache
Treatment Course
Spravato
(Esketamine)2x/week, tapered over time
TMS
(Transcranial Magnetic Stimulation)30-36 sessions over several weeks
Insurance Coverage
Spravato
(Esketamine)Covered by most plans
TMS
(Transcranial Magnetic Stimulation)Covered by most plans
Recent clinical research on Spravato
2024
J&J seeks U.S. FDA approval of SPRAVATO® (esketamine) as the first and only monotherapy for adults with treatment-resistant depression•JNJ
2024
When used with an OAD, ESK demonstrates itself as a beneficial supplement in the treatment of TRD & MDD with acute suicidal intent.•Suneeta, et al.
2019
Intranasal Esketamine (SpravatoTM) for Use in Treatment-Resistant Depression In Conjunction With an Oral Antidepressant•Bahr et al.
Frequently Asked Questions about Spravato Therapy
What is Spravato (Esketamine) Therapy?
Spravato is a nasal spray used to treat treatment-resistant depression. It works differently from traditional antidepressants by targeting NMDA receptors in the brain, offering relief for people who haven’t responded to other treatments.
How is Spravato different from traditional antidepressants?
Unlike traditional antidepressants, which adjust serotonin and other neurotransmitters, Spravato affects NMDA receptors. This allows it to provide faster relief, often within hours to days.
Is Spravato covered by insurance?
Yes, many insurance plans cover Spravato for treatment-resistant depression. Clinics will check your coverage to confirm.
What side effects can I expect from Spravato?
Most people tolerate Spravato well, but some may experience mild dizziness, nausea, headache, or dissociation (feeling disconnected). These effects are usually temporary and monitored during treatment.
Who is a good candidate for Spravato therapy?
Spravato may be recommended for individuals with treatment-resistant depression who haven’t found relief from traditional medications or who have experienced adverse effects from other therapies.
How long does each Spravato session last?
Each session includes monitoring for about two hours after administration to ensure safety and comfort.
How soon will I see results with Spravato?
Many patients feel improvements within hours or days, although full benefits may emerge over a few weeks.
How long do the effects of Spravato last?
The duration varies, but with a structured dosing schedule, patients often experience long-lasting improvements. Maintenance doses may help extend benefits.
What are the downsides of Spravato?
While highly effective, Spravato requires in-clinic administration and monitoring, which can be time-intensive. Side effects, though generally mild, may include nausea, dizziness, or temporary dissociation.
Who should not use Spravato?
Spravato is not recommended for individuals with certain health conditions. A clinician will review your medical history to assess if Spravato is right for you. You shouldn’t receive Spravato if you have ever had a brain bleed, have an arteriovenous malformation (an abnormal tangling of blood vessels), have an aneurysm or similar blood vessel disease, have a history of substance misuse, are pregnant or nursing, or are younger than 18 years old.